Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. [electronic resource]
Producer: 20090122Description: 7717-30 p. digitalISSN:- 1520-4804
- Antiviral Agents -- chemistry
- Catalysis
- Catalytic Domain
- Cell Line
- Chemistry, Pharmaceutical -- methods
- Drug Design
- HIV-1 -- enzymology
- Humans
- Hydrogen Bonding
- Inhibitory Concentration 50
- Isoquinolines -- pharmacology
- Models, Chemical
- Reverse Transcriptase Inhibitors -- chemistry
- Ribonuclease H -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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