Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. [electronic resource]
Producer: 20090506Description: 247-55 p. digitalISSN:- 1872-7786
- Administration, Oral
- Aged
- Andrographis -- chemistry
- Animals
- Cells, Cultured
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- genetics
- Diterpenes -- pharmacology
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Female
- Gene Expression Regulation, Enzymologic -- drug effects
- Hepatocytes -- cytology
- Humans
- Liver -- enzymology
- Male
- Mixed Function Oxygenases -- metabolism
- Plant Extracts -- pharmacology
- RNA, Messenger -- genetics
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
- Young Adult
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Publication Type: Journal Article
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