Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis. [electronic resource]
Producer: 20090217Description: 26-36 p. digitalISSN:- 1365-2133
- Administration, Topical
- Adolescent
- Adult
- Analysis of Variance
- Benzothiazoles -- administration & dosage
- Biomarkers -- metabolism
- Cell Proliferation -- drug effects
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Dose-Response Relationship, Drug
- Double-Blind Method
- Epidermis -- drug effects
- Female
- Gene Expression -- drug effects
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- RNA, Messenger -- analysis
- Receptors, Retinoic Acid -- genetics
- Retinal Dehydrogenase -- genetics
- Retinoic Acid 4-Hydroxylase
- Retinoids -- genetics
- Triazoles -- administration & dosage
- Young Adult
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Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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