Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse. [electronic resource]
Producer: 20090311Description: 461-72 p. digitalISSN:- 1096-0929
- Acetone -- toxicity
- Allyl Compounds -- metabolism
- Animals
- Aryl Hydrocarbon Hydroxylases -- chemistry
- Behavior, Animal -- drug effects
- Cyanides -- blood
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 CYP2E1 -- genetics
- Cytochrome P-450 CYP2E1 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- genetics
- Cytochrome P450 Family 2
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Epoxy Compounds -- metabolism
- Indicators and Reagents
- Mice
- Mice, Knockout
- Nitriles -- blood
- Solvents
- Vestibular Diseases -- chemically induced
- Vestibular Function Tests
- Vestibule, Labyrinth -- pathology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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