Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. [electronic resource]
Producer: 20090408Description: 557-64 p. digitalISSN:- 1476-5551
- Antimetabolites, Antineoplastic -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- administration & dosage
- Biotransformation -- drug effects
- Child
- Child, Preschool
- DNA Damage
- Female
- Genotype
- Humans
- Inactivation, Metabolic -- genetics
- Infant
- Male
- Mercaptopurine -- administration & dosage
- Methylation
- Methyltransferases -- analysis
- Neoplasm Proteins -- analysis
- Neoplasms, Second Primary -- enzymology
- Polymorphism, Genetic
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Recurrence
- Risk
- Scandinavian and Nordic Countries -- epidemiology
- Thioguanine -- administration & dosage
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Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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