Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. [electronic resource]
Producer: 20080908Description: 1851-63 p. digitalISSN:- 1535-7163
- Adenosine Triphosphate -- metabolism
- Administration, Oral
- Animals
- Antineoplastic Agents -- chemistry
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Glioblastoma -- drug therapy
- Humans
- Imidazoles -- chemistry
- Mice
- Mice, Nude
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- chemistry
- Protein Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Quinolines -- chemistry
- TOR Serine-Threonine Kinases
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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