Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. [electronic resource]
Producer: 20080626Description: 5422-32 p. digitalISSN:- 1529-2401
- Age Factors
- Animals
- Animals, Newborn
- Brain -- drug effects
- Cell Size -- drug effects
- Dendrites -- drug effects
- Disease Models, Animal
- Everolimus
- Immunosuppressive Agents -- therapeutic use
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation -- genetics
- Neurons -- drug effects
- Oncogene Protein v-akt -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- analogs & derivatives
- Time Factors
- Transcription Factors -- metabolism
- Tuberous Sclerosis -- drug therapy
- Tuberous Sclerosis Complex 1 Protein
- Tumor Suppressor Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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