Discovery and biological characterization of a novel series of androgen receptor modulators. [electronic resource]
Producer: 20080619Description: 440-50 p. digitalISSN:- 0007-1188
- Androgen Antagonists -- chemistry
- Androgen Receptor Antagonists
- Anilides -- pharmacology
- Animals
- Antineoplastic Agents, Hormonal -- chemistry
- Binding, Competitive
- Cell Line
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Design
- Genes, Reporter
- Humans
- Male
- Mice
- Models, Molecular
- Molecular Structure
- Nitriles -- pharmacology
- Orchiectomy
- Pilot Projects
- Prostate -- drug effects
- Prostatic Neoplasms -- drug therapy
- Protein Binding
- Rats
- Rats, Sprague-Dawley
- Receptors, Androgen -- genetics
- Reproducibility of Results
- Seminal Vesicles -- drug effects
- Small Molecule Libraries
- Stereoisomerism
- Structure-Activity Relationship
- Testosterone -- metabolism
- Tosyl Compounds -- pharmacology
- Transcriptional Activation -- drug effects
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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