L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. [electronic resource]
Producer: 20080722Description: 43-8 p. digitalISSN:- 0168-0102
- Animals
- Benzoquinones -- pharmacology
- COS Cells
- Cell Cycle Proteins -- metabolism
- Chaperonins -- metabolism
- Chlorocebus aethiops
- Cysteine Proteinase Inhibitors -- pharmacology
- HSP90 Heat-Shock Proteins -- metabolism
- Half-Life
- Humans
- Lactams, Macrocyclic -- pharmacology
- Mass Spectrometry
- Mutation -- genetics
- Novobiocin -- pharmacology
- Parkinson Disease -- genetics
- Plasmids -- genetics
- Protease Inhibitors -- pharmacology
- Proteasome Endopeptidase Complex -- genetics
- Protein Binding -- genetics
- Protein Kinases -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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