Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice. [electronic resource]
Producer: 20080813Description: 3250-9 p. digitalISSN:- 0022-1767
- Animals
- CD8-Positive T-Lymphocytes -- immunology
- Cell Differentiation -- genetics
- Chromosome Mapping
- Clonal Deletion -- genetics
- Clone Cells
- Diabetes Mellitus, Type 1 -- genetics
- Genetic Markers
- Genetic Predisposition to Disease
- Mice
- Mice, Congenic
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, Transgenic
- Quantitative Trait Loci -- immunology
- Receptors, Antigen, T-Cell, alpha-beta -- biosynthesis
- Thymus Gland -- immunology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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