Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. [electronic resource]
Producer: 20080424Description: E582-8 p. digitalISSN:- 0193-1849
- Acetylation -- drug effects
- Binding Sites
- Biological Transport -- drug effects
- Caffeine -- pharmacology
- Calcium -- pharmacology
- Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- physiology
- Cell Nucleus -- chemistry
- Cells, Cultured
- DNA -- metabolism
- Glucose Transporter Type 4 -- genetics
- Histone Deacetylases -- analysis
- Histones -- metabolism
- Humans
- MADS Domain Proteins -- metabolism
- MEF2 Transcription Factors
- Muscle Cells -- ultrastructure
- Myogenic Regulatory Factors -- metabolism
- Promoter Regions, Genetic -- genetics
- RNA, Messenger -- analysis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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