Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. [electronic resource]
Producer: 20080512Description: 7745-53 p. digitalISSN:- 0021-9258
- Alzheimer Disease -- drug therapy
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Cathepsin B -- genetics
- Cattle
- Cysteine Proteinase Inhibitors -- pharmacology
- Dipeptides -- pharmacology
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Gene Expression
- Humans
- Leucine -- analogs & derivatives
- Maze Learning -- drug effects
- Memory -- drug effects
- Mice
- Mice, Transgenic
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural
There are no comments on this title.
Log in to your account to post a comment.