A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity. [electronic resource]
Producer: 20071128Description: 995-1005 p. digitalISSN:- 1350-0872
- Amino Acid Substitution
- Animals
- Crystallography, X-Ray
- DNA, Bacterial -- metabolism
- Dimerization
- Helix-Turn-Helix Motifs
- Hemolysin Factors -- genetics
- Humans
- Listeria monocytogenes -- chemistry
- Models, Molecular
- Mutation
- Peptide Termination Factors -- chemistry
- Protein Conformation
- Trans-Activators -- chemistry
- Transcription, Genetic
- Virulence
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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