De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1. [electronic resource]
Producer: 20070316Description: 413-20 p. digitalISSN:- 1107-3756
- Androstadienes -- pharmacology
- Cell Nucleus -- drug effects
- Cells, Cultured
- Chromones -- pharmacology
- Cytoplasm -- drug effects
- DNA-Binding Proteins -- chemistry
- Down-Regulation -- drug effects
- Enzyme Activation -- drug effects
- Glycogen Synthase Kinase 3 -- metabolism
- Glycogen Synthase Kinase 3 beta
- HSP70 Heat-Shock Proteins -- genetics
- Heat Shock Transcription Factors
- Hepatocytes -- cytology
- Humans
- Hyperthermia, Induced
- Interleukin-6 -- pharmacology
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Morpholines -- pharmacology
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- drug effects
- Protein Isoforms -- metabolism
- Protein Structure, Quaternary -- drug effects
- Protein Transport -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA Interference
- RNA, Messenger -- genetics
- Transcription Factors -- chemistry
- Transcription, Genetic -- drug effects
- Up-Regulation -- drug effects
- Wortmannin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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