Different target range and cytotoxic specificity of adaphostin and 17-allylamino-17-demethoxygeldanamycin in imatinib-resistant and sensitive cell lines. [electronic resource]
Producer: 20070413Description: 421-6 p. digitalISSN:- 0887-6924
- Adamantane -- adverse effects
- Animals
- Antineoplastic Agents -- pharmacology
- Benzamides
- Benzoquinones -- adverse effects
- Cell Line, Transformed -- drug effects
- Cell Line, Tumor -- drug effects
- Clone Cells -- drug effects
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Fusion Proteins, bcr-abl -- antagonists & inhibitors
- Gene Expression Regulation, Leukemic -- drug effects
- Genes, abl
- HSP90 Heat-Shock Proteins -- physiology
- Humans
- Hydrogen Peroxide -- pharmacology
- Hydroquinones -- adverse effects
- Imatinib Mesylate
- Lactams, Macrocyclic -- adverse effects
- Mice
- Mutant Proteins -- genetics
- Mutation, Missense
- Oxidative Stress -- drug effects
- Piperazines -- pharmacology
- Point Mutation
- Protein Kinase Inhibitors -- adverse effects
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-akt -- biosynthesis
- Proto-Oncogene Proteins c-bcr -- biosynthesis
- Pyrimidines -- pharmacology
- Reactive Oxygen Species
- Recombinant Fusion Proteins -- genetics
- STAT5 Transcription Factor -- biosynthesis
- Signal Transduction -- drug effects
- Substrate Specificity
- Transfection
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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