PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax. [electronic resource]
Producer: 20070201Description: 203-12 p. digitalISSN:- 0006-291X
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Aza Compounds -- pharmacology
- Binding Sites
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Cell Line, Tumor
- Extracellular Signal-Regulated MAP Kinases -- genetics
- Humans
- Intracellular Signaling Peptides and Proteins
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Mutation -- genetics
- Phosphorylation
- Promoter Regions, Genetic -- genetics
- Protein Binding
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogene Proteins -- genetics
- Signal Transduction
- Tumor Suppressor Protein p53 -- genetics
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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