Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. [electronic resource]
Producer: 20070202Description: 481-9 p. digitalISSN:- 0007-1188
- Adult
- Antidepressive Agents, Second-Generation -- adverse effects
- Blotting, Western
- Cell Line
- Cell Membrane -- drug effects
- Cisapride -- pharmacology
- Dose-Response Relationship, Drug
- Drug Overdose
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- Female
- Fluoxetine -- adverse effects
- Humans
- Long QT Syndrome -- chemically induced
- Membrane Potentials -- drug effects
- Muscle Proteins -- antagonists & inhibitors
- Mutation -- genetics
- NAV1.5 Voltage-Gated Sodium Channel
- Patch-Clamp Techniques
- Piperidines -- pharmacology
- Protein Transport -- drug effects
- Pyridines -- pharmacology
- Sodium Channels -- genetics
- Time Factors
- Transfection
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Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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