Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes. [electronic resource]
Producer: 20070112Description: 979-93 p. digitalISSN:- 0022-2836
- Animals
- Binding Sites
- Cathepsin B -- chemistry
- Cattle
- Crystallography, X-Ray
- Cysteine Proteinase Inhibitors -- chemical synthesis
- Drug Design
- Epoxy Compounds
- Hydrogen Bonding
- Hydrophobic and Hydrophilic Interactions
- Inhibitory Concentration 50
- Models, Molecular
- Molecular Structure
- Protein Conformation
- Protein Structure, Secondary
- Static Electricity
- Structure-Activity Relationship
- Substrate Specificity
- Succinic Acid
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Publication Type: Journal Article
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