Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. [electronic resource]
Producer: 20061005Description: 993-1000 p. digitalISSN:- 0006-4971
- Apoptosis -- drug effects
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins -- physiology
- Cells, Cultured
- DNA-Binding Proteins -- physiology
- Drug Resistance, Neoplasm
- Drug Synergism
- Drug Therapy, Combination
- Humans
- Imidazoles -- pharmacology
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Mutation
- Piperazines -- pharmacology
- Protein Serine-Threonine Kinases -- physiology
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Transcription, Genetic
- Tumor Suppressor Protein p53 -- genetics
- Tumor Suppressor Proteins -- physiology
- Vidarabine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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