Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats. [electronic resource]
Producer: 20060616Description: 435-44 p. digitalISSN:- 0887-4476
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer -- pharmacology
- Adenosine -- antagonists & inhibitors
- Adrenergic Agents -- toxicity
- Animals
- Caffeine -- analogs & derivatives
- Corpus Striatum -- drug effects
- Dynorphins -- biosynthesis
- Dyskinesias -- etiology
- Enkephalins -- biosynthesis
- Immunohistochemistry
- In Situ Hybridization
- Levodopa -- adverse effects
- Male
- Oxidopamine -- toxicity
- Parkinsonian Disorders -- drug therapy
- Protein Precursors -- biosynthesis
- RNA, Messenger -- analysis
- Rats
- Rats, Sprague-Dawley
- Receptors, Opioid, kappa -- agonists
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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