The novel chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA(3)-DTDA) promotes stable binding of His-tagged proteins to liposomal membranes: potent anti-tumor responses induced by simultaneously targeting antigen, cytokine and costimulatory signals to T cells. [electronic resource]
Producer: 20051223Description: 104-16 p. digitalISSN:- 0006-3002
- Amines -- chemistry
- Animals
- Antigens -- metabolism
- B7-1 Antigen -- chemistry
- Biosensing Techniques
- CD40 Antigens -- chemistry
- Cell Membrane -- metabolism
- Cell Proliferation
- Chelating Agents -- pharmacology
- Cytokines -- metabolism
- Dose-Response Relationship, Drug
- Female
- Histidine -- chemistry
- Interleukin-12 -- metabolism
- Interleukin-2 -- metabolism
- Kinetics
- Lipids
- Liposomes -- chemistry
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred DBA
- Models, Chemical
- Neoplasm Transplantation
- Nitrilotriacetic Acid -- analogs & derivatives
- Protein Binding
- Recombinant Proteins -- chemistry
- T-Lymphocytes -- cytology
- Temperature
- Time Factors
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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