TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates. [electronic resource]
Producer: 20060331Description: 410-22 p. digitalISSN:- 0022-3565
- Acoustic Stimulation
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Agonists -- pharmacology
- Animals
- Anti-Anxiety Agents
- Anticonvulsants -- pharmacology
- Autoradiography
- Conditioning, Operant -- drug effects
- Convulsants -- pharmacology
- Drinking -- drug effects
- Emotions -- drug effects
- Fear -- drug effects
- Flumazenil -- metabolism
- GABA Modulators -- metabolism
- GABA-A Receptor Agonists
- Humans
- Male
- Mice
- Pentylenetetrazole -- antagonists & inhibitors
- Postural Balance -- drug effects
- Protein Binding
- Pyridazines -- pharmacology
- Radioligand Assay
- Rats
- Rats, Sprague-Dawley
- Receptors, GABA-A
- Recombinant Proteins -- metabolism
- Reflex, Startle -- drug effects
- Saimiri
- Substance Withdrawal Syndrome -- psychology
- Triazoles -- pharmacology
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Publication Type: Journal Article
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