Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype". [electronic resource]
Producer: 20051128Description: 4555-60 p. digitalISSN:- 0022-1767
- Active Transport, Cell Nucleus -- physiology
- Adult
- Autoantibodies -- blood
- Biomarkers
- Cell Nucleus -- metabolism
- Cells, Cultured
- Extracellular Matrix Proteins -- biosynthesis
- Fibrillin-1
- Fibrillins
- Fibroblasts -- metabolism
- Humans
- Microfilament Proteins -- immunology
- Middle Aged
- Phosphorylation
- Scleroderma, Systemic -- blood
- Transforming Growth Factor beta -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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