Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. [electronic resource]
Producer: 20051011Description: 1407-20 p. digitalISSN:- 1357-2725
- Cell Cycle Proteins -- biosynthesis
- Cell Proliferation -- drug effects
- Cells, Cultured
- Cellular Senescence -- drug effects
- Comet Assay
- Cyclin-Dependent Kinase Inhibitor p21
- DNA Damage -- genetics
- DNA Repair -- genetics
- Diploidy
- Electrophoretic Mobility Shift Assay
- Fibroblasts -- drug effects
- Humans
- Hydrogen Peroxide -- pharmacology
- Intracellular Signaling Peptides and Proteins -- metabolism
- Oxidative Stress
- Telomere -- drug effects
- Time Factors
- Tumor Suppressor Protein p53 -- biosynthesis
- beta-Galactosidase -- metabolism
- GADD45 Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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