Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. [electronic resource]
Producer: 20050314Description: 780-6 p. digitalISSN:- 0008-5472
- Ataxia Telangiectasia Mutated Proteins
- CDC2 Protein Kinase -- antagonists & inhibitors
- CDC2-CDC28 Kinases -- antagonists & inhibitors
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Checkpoint Kinase 1
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- DNA Damage -- physiology
- DNA-Binding Proteins -- metabolism
- Down-Regulation
- Enzyme Inhibitors -- pharmacology
- HeLa Cells
- Histones -- metabolism
- Humans
- Kinetin
- Protein Kinases -- biosynthesis
- Protein Serine-Threonine Kinases -- metabolism
- Purines -- pharmacology
- Roscovitine
- Tumor Suppressor Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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