Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. [electronic resource]
Producer: 20060713Description: 271-89 p. digitalISSN:- 0077-8923
- Animals
- Animals, Newborn
- Apoptosis -- drug effects
- Blotting, Western -- methods
- Caspase 3
- Caspases -- metabolism
- Cell Count -- methods
- DNA Fragmentation -- drug effects
- Dopamine -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay -- methods
- Flow Cytometry -- methods
- Immunoprecipitation -- methods
- Mesencephalon -- cytology
- Mutation -- physiology
- Neurons -- drug effects
- Organometallic Compounds -- pharmacology
- Protein Kinase C-delta -- metabolism
- Rats
- Reactive Oxygen Species -- metabolism
- Systole
- Transfection -- methods
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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