Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway. [electronic resource]
Producer: 20050519Description: 45-53 p. digitalISSN:- 1073-2322
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Blotting, Western
- Cell Line
- Cell Nucleus -- metabolism
- Cell Survival
- Cell-Free System
- Cysteine -- chemistry
- Cytosol -- metabolism
- DNA -- metabolism
- Dimerization
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Ethacrynic Acid -- metabolism
- Genes, Reporter
- Glutathione -- metabolism
- Humans
- I-kappa B Proteins -- metabolism
- Inflammation
- Lipopolysaccharides -- metabolism
- Mice
- Models, Chemical
- Models, Molecular
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- NF-kappa B p50 Subunit
- Phosphorylation
- Recombinant Proteins -- chemistry
- Reverse Transcriptase Polymerase Chain Reaction
- Serine -- chemistry
- Signal Transduction
- Transcription Factor RelA
- Transcription Factors -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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