Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation. [electronic resource]
Producer: 20050127Description: 369-78 p. digitalISSN:- 0003-9861
- Aflatoxin B1 -- chemistry
- Animals
- Biotransformation
- Butadienes -- chemistry
- Cross-Linking Reagents -- chemistry
- DNA
- DNA Adducts -- chemistry
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Drug
- Enzyme Activation
- Escherichia coli -- drug effects
- Ethylene Dibromide -- chemistry
- Forecasting
- Genes, Bacterial
- Glutathione -- metabolism
- Half-Life
- Humans
- Hydrolysis
- Kinetics
- Lysine -- metabolism
- Models, Chemical
- Molecular Structure
- Mutagenicity Tests
- Mutagens -- chemistry
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase -- metabolism
- Oxidation-Reduction
- Salmonella typhimurium -- drug effects
- Signal Transduction
- Tetrachloroethylene -- chemistry
- Trichloroethylene -- chemistry
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
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