HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. [electronic resource]
Producer: 20050303Description: 1456-66 p. digitalISSN:- 0006-4971
- Acute Disease
- Animals
- Bone Marrow Cells -- metabolism
- Cell Differentiation -- genetics
- Cell Line, Transformed
- Cell Proliferation
- Cell Transformation, Neoplastic -- pathology
- Erythropoiesis -- genetics
- Female
- Homeodomain Proteins -- biosynthesis
- Karyotyping
- Leukemia, Myeloid -- blood
- Lymphopoiesis -- genetics
- Mice
- Mice, Congenic
- Mice, Inbred C57BL
- Myeloid Ecotropic Viral Integration Site 1 Protein
- Myeloid Progenitor Cells -- metabolism
- Neoplasm Proteins -- physiology
- Phenotype
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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