Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. [electronic resource]
Producer: 20050527Description: 971-80 p. digitalISSN:- 1524-4571
- Acetylation -- drug effects
- Alkaloids
- Animals
- Apoptosis -- drug effects
- Atrial Natriuretic Factor -- biosynthesis
- Benzamides -- pharmacology
- Benzophenanthridines
- Cell Nucleus -- enzymology
- Cell Size -- drug effects
- Cell Survival
- Cells, Cultured -- cytology
- Culture Media, Serum-Free
- Cysteine Proteinase Inhibitors -- pharmacology
- Dogs
- Gene Silencing -- physiology
- Genes, Dominant
- Genes, p53
- Heart Failure -- enzymology
- Heart Ventricles -- cytology
- Hydroxamic Acids -- pharmacology
- Hypertrophy
- Hypertrophy, Left Ventricular -- enzymology
- Longevity -- genetics
- Mice
- Myocytes, Cardiac -- cytology
- Naphthols -- pharmacology
- Niacinamide -- pharmacology
- Phenanthridines -- pharmacology
- Protein Processing, Post-Translational -- drug effects
- Rats
- Rats, Wistar
- Recombinant Fusion Proteins -- physiology
- Sirtuin 1
- Sirtuins -- antagonists & inhibitors
- Transcription, Genetic -- drug effects
- Tumor Suppressor Protein p53 -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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