Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. [electronic resource]
Producer: 20040908Description: 180-8 p. digitalISSN:- 0894-1491
- Animals
- Astrocytes -- metabolism
- Cell Differentiation -- genetics
- Cell Size -- genetics
- Cells, Cultured
- Central Nervous System -- metabolism
- Contact Inhibition -- genetics
- Down-Regulation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Mice
- Mice, Knockout
- Monomeric GTP-Binding Proteins -- antagonists & inhibitors
- Neuropeptides -- antagonists & inhibitors
- Protein Kinase Inhibitors
- Protein Kinases -- metabolism
- Proteins -- genetics
- RNA Interference
- Ras Homolog Enriched in Brain Protein
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Signal Transduction -- genetics
- TOR Serine-Threonine Kinases
- Transfection
- Tuberous Sclerosis -- genetics
- Tuberous Sclerosis Complex 1 Protein
- Tumor Suppressor Proteins
- Up-Regulation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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