The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes. [electronic resource]
Producer: 20040714Description: 356-68 p. digitalISSN:- 0894-1491
- Animals
- Animals, Newborn
- Apoptosis -- drug effects
- Astrocytes -- drug effects
- Caspase 3
- Caspases -- metabolism
- Cells, Cultured
- Enzyme Inhibitors -- pharmacology
- Glycogen Synthase Kinase 3 -- metabolism
- Glycogen Synthase Kinase 3 beta
- Guanosine -- metabolism
- MAP Kinase Signaling System -- drug effects
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Purinergic Antagonists
- Purinergic P1 Receptor Antagonists
- RNA, Messenger -- drug effects
- Rats
- Receptors, Purinergic -- metabolism
- Receptors, Purinergic P1 -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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