p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. [electronic resource]
Producer: 20040701Description: 25260-7 p. digitalISSN:- 0021-9258
- CDC2-CDC28 Kinases -- genetics
- Calcitriol -- pharmacology
- Cell Cycle Proteins -- physiology
- Cell Division -- drug effects
- Cell Line, Tumor
- Cyclin E -- genetics
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclins -- physiology
- Down-Regulation
- Female
- G1 Phase -- drug effects
- Gene Expression Regulation, Neoplastic
- Humans
- Mitosis
- Ovarian Neoplasms -- pathology
- Phosphorylation
- S-Phase Kinase-Associated Proteins -- physiology
- SKP Cullin F-Box Protein Ligases -- physiology
- Tumor Suppressor Proteins -- physiology
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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