The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids. [electronic resource]
Producer: 20041209Description: 8 p. digitalISSN:- 1476-4598
- Active Transport, Cell Nucleus -- physiology
- Cell Line, Tumor
- Cell Nucleus -- metabolism
- DNA, Neoplasm -- metabolism
- DNA-Binding Proteins -- antagonists & inhibitors
- Enzyme Activation -- physiology
- Gene Expression Regulation -- physiology
- Humans
- Leupeptins -- pharmacology
- Ligands
- Macromolecular Substances -- antagonists & inhibitors
- Matrix Metalloproteinase 9 -- metabolism
- NF-kappa B -- genetics
- Neoplasm Metastasis -- pathology
- Neoplasm Proteins
- Protein Transport -- physiology
- Receptors, Retinoic Acid -- antagonists & inhibitors
- Repressor Proteins -- physiology
- Retinoids
- Tissue Inhibitor of Metalloproteinase-1 -- metabolism
- Transcriptional Activation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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