Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region. [electronic resource]
Producer: 20040913Description: 149-54 p. digitalISSN:- 0090-9556
- Amino Acid Sequence
- Animals
- Biotransformation -- drug effects
- Blotting, Western
- COS Cells
- Cell Line, Tumor
- Chlorocebus aethiops
- Clotrimazole -- pharmacology
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- genetics
- DNA -- genetics
- Electrophoretic Mobility Shift Assay
- Enhancer Elements, Genetic -- genetics
- Exons -- genetics
- Genes, Reporter -- genetics
- Humans
- Immunohistochemistry
- Luciferases -- genetics
- Molecular Sequence Data
- Paclitaxel -- pharmacology
- Plasmids -- genetics
- Pregnane X Receptor
- Promoter Regions, Genetic -- genetics
- Receptors, Cytoplasmic and Nuclear -- genetics
- Receptors, Steroid -- genetics
- Rifampin -- pharmacology
- Transcriptional Activation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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