Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling. [electronic resource]
Producer: 20040520Description: 4340-6 p. digitalISSN:- 1078-0432
- Breast Neoplasms -- drug therapy
- Chromones -- pharmacology
- Down-Regulation
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- pharmacology
- Epidermal Growth Factor -- antagonists & inhibitors
- Female
- Gefitinib
- Genes, Tumor Suppressor
- Humans
- Morpholines -- pharmacology
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Phosphoric Monoester Hydrolases -- genetics
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Quinazolines -- pharmacology
- Receptor, ErbB-2 -- antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Transfection
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article
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