Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. [electronic resource]
Producer: 20031205Description: 1387-401 p. digitalISSN:- 0953-816X
- 1-Methyl-4-phenylpyridinium -- toxicity
- Animals
- Apoptosis -- drug effects
- Benzimidazoles -- metabolism
- Caspase 3
- Caspase 9
- Caspase Inhibitors
- Caspases -- metabolism
- Cell Line
- Coumarins -- metabolism
- Cytochromes c -- metabolism
- DNA Fragmentation
- Dopamine -- metabolism
- Dose-Response Relationship, Drug
- Drug Interactions
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry -- instrumentation
- Free Radical Scavengers -- pharmacology
- Gene Expression -- drug effects
- Herbicides -- toxicity
- In Vitro Techniques
- Manganese Compounds -- pharmacology
- Mesencephalon -- cytology
- Metalloporphyrins -- pharmacology
- Nerve Degeneration -- chemically induced
- Organometallic Compounds
- Oxidative Stress -- drug effects
- Precipitin Tests
- Protein Kinase C -- classification
- Protein Kinase C-delta
- Rats
- Reactive Oxygen Species -- metabolism
- Time Factors
- Transfection -- methods
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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