Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. [electronic resource]
Producer: 20031002Description: 33351-63 p. digitalISSN:- 0021-9258
- 1-Methyl-3-isobutylxanthine -- pharmacology
- 3',5'-Cyclic-AMP Phosphodiesterases -- chemistry
- Alanine -- chemistry
- Amino Acid Sequence
- Animals
- COS Cells
- Cloning, Molecular
- Colforsin -- pharmacology
- Cyclic AMP -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 4
- DNA, Complementary -- metabolism
- Dose-Response Relationship, Drug
- Electrophoresis, Polyacrylamide Gel
- Gene Deletion
- Glutathione Transferase -- metabolism
- Humans
- Immunoblotting
- Inhibitory Concentration 50
- Intracellular Signaling Peptides and Proteins
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Phosphorylation
- Precipitin Tests
- Protein Binding
- Protein Isoforms
- Protein Structure, Tertiary
- Proteins -- chemistry
- Rats
- Recombinant Fusion Proteins -- metabolism
- Rolipram -- pharmacology
- Saccharomyces cerevisiae -- metabolism
- Sequence Homology, Amino Acid
- Time Factors
- Two-Hybrid System Techniques
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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