In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. [electronic resource]
Producer: 20030703Description: 1582-93 p. digitalISSN:- 0004-3591
- Animals
- Cartilage, Articular -- drug effects
- Chondrocytes -- drug effects
- Collagenases -- metabolism
- Disease Models, Animal
- Enzyme Inhibitors -- pharmacology
- Fluorobenzenes -- pharmacology
- Hindlimb -- surgery
- Immunohistochemistry
- Longitudinal Ligaments -- surgery
- MAP Kinase Kinase 1
- MAP Kinase Kinase 2
- Male
- Matrix Metalloproteinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Mitogen-Activated Protein Kinases -- metabolism
- Osteoarthritis, Knee -- drug therapy
- Phosphorylation
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Rabbits
- Synovial Membrane -- drug effects
- Synovitis -- drug therapy
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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