Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis. [electronic resource]
Producer: 20030718Description: 21295-306 p. digitalISSN:- 0021-9258
- Amino Acid Chloromethyl Ketones -- pharmacology
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- CASP8 and FADD-Like Apoptosis Regulating Protein
- Carrier Proteins -- genetics
- Caspase 3
- Caspase 8
- Caspase 9
- Caspases -- metabolism
- Cathepsin B -- metabolism
- Cell Nucleus
- Cells, Cultured
- Chromones -- pharmacology
- Cycloheximide -- pharmacology
- Cysteine Proteinase Inhibitors -- pharmacology
- Endothelium, Vascular -- cytology
- Enzyme Inhibitors -- pharmacology
- Humans
- Interleukin-1 -- pharmacology
- Intracellular Signaling Peptides and Proteins
- Morpholines -- pharmacology
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Protein Serine-Threonine Kinases
- Protein Synthesis Inhibitors -- pharmacology
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Retroviridae -- genetics
- Transduction, Genetic
- Tumor Necrosis Factor-alpha -- pharmacology
- Umbilical Veins -- cytology
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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