Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion. [electronic resource]
Producer: 20030912Description: 718-24 p. digitalISSN:- 0006-4971
- Amino Acid Sequence
- Anemia, Sickle Cell -- blood
- Arterial Occlusive Diseases -- blood
- Binding Sites
- Biosensing Techniques
- Calcium -- metabolism
- Cell Adhesion -- drug effects
- Cells, Cultured -- drug effects
- Depression, Chemical
- Endothelium, Vascular -- cytology
- Enzyme-Linked Immunosorbent Assay
- Epitopes -- immunology
- Erythrocytes, Abnormal -- drug effects
- Humans
- Immunoglobulin Variable Region -- immunology
- Molecular Sequence Data
- Peptide Library
- Protein Structure, Tertiary
- Recombinant Proteins -- pharmacology
- Sequence Alignment
- Sequence Homology, Amino Acid
- Thrombospondins -- chemistry
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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