Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability. [electronic resource]
Producer: 20030307Description: 5416-24 p. digitalISSN:- 1362-4962
- Adenosine Triphosphatases -- chemistry
- Adenosine Triphosphate -- metabolism
- Amino Acid Sequence
- Amino Acid Substitution
- Binding Sites -- genetics
- DNA -- genetics
- DNA Helicases -- chemistry
- DNA Topoisomerases, Type II -- chemistry
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Genetic Complementation Test
- Humans
- Hydrolysis -- drug effects
- Kinetics
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- Saccharomyces cerevisiae -- genetics
- Sequence Homology, Amino Acid
- Serine -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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