A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor. [electronic resource]
Producer: 20030206Description: 43137-42 p. digitalISSN:- 0021-9258
- Allantois -- drug effects
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Breast Neoplasms
- Cell Division
- Cells, Cultured
- Chick Embryo
- Chorion -- drug effects
- DNA Primers
- DNA, Complementary
- Endothelial Growth Factors -- pharmacology
- Endothelium, Vascular -- cytology
- Female
- Humans
- Intercellular Signaling Peptides and Proteins -- pharmacology
- Lymphokines -- pharmacology
- Neoplasm Metastasis -- prevention & control
- Neovascularization, Pathologic -- prevention & control
- Neovascularization, Physiologic -- drug effects
- Oligopeptides -- chemistry
- Peptide Fragments -- chemistry
- Peptide Library
- Protein-Tyrosine Kinases -- metabolism
- Recombinant Proteins -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Substrate Specificity
- Tumor Cells, Cultured
- Umbilical Veins
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factor Receptor-2 -- antagonists & inhibitors
- Vascular Endothelial Growth Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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