The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway. [electronic resource]
Producer: 20020920Description: 269-76 p. digitalISSN:- 0091-6749
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Antigens, CD -- biosynthesis
- Antigens, CD1 -- biosynthesis
- B7-1 Antigen -- biosynthesis
- B7-2 Antigen
- Biological Transport
- CD40 Antigens -- biosynthesis
- Calcium-Calmodulin-Dependent Protein Kinases -- metabolism
- Cell Differentiation
- Cells, Cultured
- Dendritic Cells -- cytology
- Down-Regulation
- Endocytosis -- drug effects
- Histocompatibility Antigens Class II -- biosynthesis
- Humans
- I-kappa B Proteins -- metabolism
- Immunoglobulins -- biosynthesis
- Interleukin-12 -- metabolism
- Lipopolysaccharides -- pharmacology
- MAP Kinase Kinase 3
- MAP Kinase Kinase 6
- MAP Kinase Signaling System
- Membrane Glycoproteins -- biosynthesis
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Mitogen-Activated Protein Kinases -- metabolism
- Monocytes -- cytology
- NF-kappa B -- antagonists & inhibitors
- Phosphorylation
- Protein-Tyrosine Kinases -- metabolism
- Sesquiterpenes -- pharmacology
- Tumor Necrosis Factor-alpha -- metabolism
- Up-Regulation -- drug effects
- p38 Mitogen-Activated Protein Kinases
- CD83 Antigen
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Publication Type: Journal Article
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