Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH. [electronic resource]
Producer: 20020408Description: 543-53 p. digitalISSN:- 0945-053X
- Aggrecans
- Amino Acid Sequence
- Animals
- Binding Sites
- Cartilage, Articular -- metabolism
- Cathepsin D -- metabolism
- Cattle
- Chondroitin Sulfates -- metabolism
- Culture Techniques
- Extracellular Matrix -- metabolism
- Extracellular Matrix Proteins
- Hydrogen-Ion Concentration
- Lectins, C-Type
- Peptide Fragments -- chemistry
- Protein Structure, Tertiary
- Proteoglycans -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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