Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and -A10 genes and induces apoptosis in a human leukemia cell line, THP-1. [electronic resource]
Producer: 20011204Description: 1743-9 p. digitalISSN:- 0887-6924
- Apoptosis
- Cell Division
- DNA-Binding Proteins -- biosynthesis
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Gene Targeting
- HL-60 Cells
- Histone-Lysine N-Methyltransferase
- Homeobox A10 Proteins
- Homeodomain Proteins -- biosynthesis
- Humans
- K562 Cells
- Leukemia -- genetics
- Myeloid-Lymphoid Leukemia Protein
- Neoplasm Proteins
- Nuclear Proteins -- genetics
- Oligodeoxyribonucleotides, Antisense -- pharmacology
- Oncogene Proteins, Fusion -- genetics
- Proto-Oncogenes
- RNA, Neoplasm -- biosynthesis
- Transcription Factors
- Transcription, Genetic
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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