The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. [electronic resource]
Producer: 20011101Description: 36788-96 p. digitalISSN:- 0021-9258
- Alzheimer Disease -- metabolism
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor -- chemistry
- Animals
- Aspartic Acid Endopeptidases -- chemistry
- Biotinylation
- Catalytic Domain
- Cell Line
- Cell Membrane -- metabolism
- Endopeptidases
- Endoplasmic Reticulum -- metabolism
- Golgi Apparatus -- metabolism
- Green Fluorescent Proteins
- Humans
- Luminescent Proteins -- metabolism
- Mice
- Microscopy, Fluorescence
- Models, Genetic
- Plasmids -- metabolism
- Protein Structure, Tertiary
- Recombinant Fusion Proteins -- metabolism
- Substrate Specificity
- Sucrose -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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