SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. [electronic resource]
Producer: 20010531Description: 29-35 p. digitalISSN:- 1061-4036
- Antineoplastic Agents -- therapeutic use
- Carcinoma, Hepatocellular -- genetics
- Carrier Proteins -- genetics
- CpG Islands
- DNA Methylation
- DNA-Binding Proteins -- metabolism
- Gene Silencing
- Genes, Tumor Suppressor
- Genetic Therapy
- Humans
- Intracellular Signaling Peptides and Proteins
- Janus Kinase 2
- Liver Neoplasms -- genetics
- Molecular Sequence Data
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins
- Repressor Proteins
- STAT3 Transcription Factor
- Signal Transduction
- Suppressor of Cytokine Signaling 1 Protein
- Suppressor of Cytokine Signaling Proteins
- Trans-Activators -- metabolism
- Tyrphostins -- therapeutic use
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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