A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. [electronic resource]
Producer: 20010927Description: 289-99 p. digitalISSN:- 1074-5521
- Adenine Nucleotides -- metabolism
- Benzoquinones
- Binding, Competitive
- Breast Neoplasms -- pathology
- Cell Cycle -- drug effects
- Cell Differentiation -- drug effects
- Drug Design
- Female
- HSP90 Heat-Shock Proteins -- metabolism
- Humans
- Lactams, Macrocyclic
- Protein Binding
- Quinones -- metabolism
- Receptor, ErbB-2 -- drug effects
- Tumor Cells, Cultured -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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