16(R)-hydroxyeicosatetraenoic acid, a novel cytochrome P450 product of arachidonic acid, suppresses activation of human polymorphonuclear leukocyte and reduces intracranial pressure in a rabbit model of thromboembolic stroke. [electronic resource]
Producer: 20010208Description: 1410-8; discussion 1418-9 p. digitalISSN:- 0148-396X
- Animals
- Arachidonic Acid -- metabolism
- Cell Adhesion -- drug effects
- Cell Aggregation -- drug effects
- Cytochrome P-450 Enzyme System -- metabolism
- Drug Synergism
- Fibrinolytic Agents -- pharmacology
- Humans
- Hydroxyeicosatetraenoic Acids -- pharmacology
- Intracranial Embolism and Thrombosis -- complications
- Intracranial Pressure -- drug effects
- Leukotriene B4 -- antagonists & inhibitors
- Neutrophils -- drug effects
- Rabbits
- Single-Blind Method
- Stroke -- etiology
- Tissue Plasminogen Activator -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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